منابع مشابه
Quality Control of mRNA Function
be coupled to each other as well, a feat also thought to Most eukaryotic cellular proteins are generated by transbe orchestrated by the CTD as an additional measure lation of mRNAs that have successfully passed a number of QC. Efficient capping enhances both splicing and 39 of steps to insure their quality. Transcripts that fail to end formation, and efficient 39 end formation enhances pass sel...
متن کاملmRNA quality control goes transcriptional
Eukaryotic mRNAs are extensively processed to generate functional transcripts, which are 5' capped, spliced and 3' polyadenylated. Accumulation of unprocessed (aberrant) mRNAs can be deleterious for the cell, hence processing fidelity is closely monitored by QC (quality control) mechanisms that identify erroneous transcripts and initiate their selective removal. Nucleases including Xrn2/Rat1 an...
متن کاملLinks between mRNA splicing, mRNA quality control, and intellectual disability.
In recent years, the impairment of RNA binding proteins that play key roles in the post-transcriptional regulation of gene expression has been linked to numerous neurological diseases. These RNA binding proteins perform critical mRNA processing steps in the nucleus, including splicing, polyadenylation, and export. In many cases, these RNA binding proteins are ubiquitously expressed raising key ...
متن کاملmRNA and microRNA quality control for RT-qPCR analysis.
The importance of high quality sample material, i.e. non-degraded or fragmented RNA, for classical gene expression profiling is well documented. Hence, the analysis of RNA quality is a valuable tool in the preparation of methods like RT-qPCR and microarray analysis. For verification of RNA integrity, today the use of automated capillary electrophoresis is state of the art. Following the recentl...
متن کاملmRNA quality control: Marking the message for life or death
A protein complex deposited upstream of exon-exon junctions after pre-mRNA splicing may serve a dual role in mRNA quality control by directing mRNA nuclear export and, possibly, serving as a downstream 'mark' for nonsense-mediated decay.
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ژورنال
عنوان ژورنال: Science
سال: 2016
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.354.6317.1246-b